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Increased transcripts in the DRG of Brn3a knockout mouse |
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| Transcript |
Symbol |
Class |
WT |
HT |
KO |
KO/WT |
|
|
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| Chordin-like 1 |
Chrdl1 |
Dev |
5 |
2 |
134 |
27.4 |
| Musculin (MyoR) |
Msc |
TX |
211 |
675 |
1,260 |
6.0 |
| Insulinoma-associated 1 |
Insm12 |
TX |
153 |
301 |
827 |
5.4 |
| GABA transporter 1 (Gabt1) |
Slc6a1 |
NT |
74 |
93 |
397 |
5.3 |
| Microfibrillar-associated 4 |
Mfap4 |
Unk |
112 |
370 |
559 |
5.0 |
| Secretogranin II |
Scg2 |
SY |
206 |
253 |
966 |
4.7 |
| C-fos induced growth factor (VEGF-D) |
Figf |
Dev |
76 |
102 |
319 |
4.2 |
| Guanylate cyclase 1, alpha 3 |
Gucy1a3 |
ST |
50 |
82 |
205 |
4.1 |
| Neurogenic differentiation 6 (Math2, Nex) |
Neurod6 |
TX |
83 |
200 |
344 |
4.1 |
| Somatostatin |
Sst |
NT |
215 |
382 |
830 |
3.9 |
| Neurexin III |
Nrxn34 |
SY |
367 |
961 |
1,412 |
3.8 |
| Bruno-like 4 |
Brunol43 |
Other |
154 |
274 |
588 |
3.8 |
| Cell adhesion molecule with homology to L1CAM |
Chl1 |
AX |
128 |
127 |
466 |
3.6 |
| Junctophilin 1 |
Jph1 |
Other |
74 |
119 |
262 |
3.5 |
| Glutamate receptor, ionotropic, AMPA4 |
Gria43 |
NT |
46 |
80 |
161 |
3.5 |
| Glutamate receptor, ionotropic, AMPA3 |
Gria3 |
NT |
40 |
66 |
138 |
3.5 |
| Zinc finger homeobox 1b |
Zfhx1b2 |
TX |
81 |
127 |
270 |
3.3 |
| Nel-like 2 |
Nell2 |
AX |
383 |
331 |
1,215 |
3.2 |
| Follistatin-like 5 |
Fstl52 |
Dev |
281 |
389 |
885 |
3.2 |
| Disabled homolog 1 |
Dab12 |
AX |
90 |
42 |
272 |
3.0 |
| Mannan-binding lectin serine protease 1 |
Masp1 |
Other |
95 |
101 |
282 |
3.0 |
| Selected |
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| Semaphorin 3C |
Sema3c2 |
AX |
589 |
723 |
1,732 |
2.9 |
| Cholecystokinin A receptor |
Cckar |
NT |
95 |
161 |
269 |
2.8 |
| Serotonin receptor 3A |
Htr3a |
NT |
778 |
1,160 |
2,090 |
2.7 |
| Homeobox A5 |
Hoxa5 |
TX |
628 |
896 |
1,493 |
2.4 |
| Neurogenic differentiation 1 |
Neurod12 |
TX |
1,048 |
1,468 |
2,440 |
2.3 |
| p21-activated kinase 3 |
Pak32 |
SY |
246 |
270 |
568 |
2.3 |
| Semaphorin 3D |
Sema3d |
AX |
318 |
365 |
725 |
2.3 |
| Protocadherin 17 |
Pcdh172 |
AX |
331 |
340 |
746 |
2.3 |
| Spondin 1, (f-spondin) |
Spon1 |
AX |
629 |
778 |
1,413 |
2.2 |
| K+ voltage-gated channel, Isk family |
Kcne1l |
NT |
613 |
813 |
1,328 |
2.2 |
| Deleted in colorectal carcinoma |
Dcc |
AX |
93 |
101 |
200 |
2.2 |
| Netrin G1 |
Ntng1 |
AX |
388 |
556 |
812 |
2.1 |
| Neuropilin 2 |
Nrp2 |
AX |
509 |
485 |
1,063 |
2.1 |
| Cadherin 22 |
Cdh22 |
AX |
199 |
226 |
414 |
2.1 |
| Synapsin II |
Syn24 |
SY |
643 |
688 |
1,324 |
2.1 |
| Glutamate receptor, ionotropic, kainate 1 |
Grik1 |
NT |
221 |
241 |
455 |
2.1 |
| Protocadherin 8 |
Pcdh82 |
AX |
278 |
398 |
569 |
2.0 |
| GDNF receptor alpha 2 |
Gfra2 |
Dev |
363 |
436 |
735 |
2.0 |
| Nescient helix loop helix 2 (Nscl2) |
Nhlh2 |
TX |
1,222 |
1,996 |
2,446 |
2.0 |
|
Data for one of two independent experiments are shown. All listed transcripts showed increased expression (change p < 0.005) in two independent replicates. Data are complete for all replicated changes above three-fold, and selected data appear for transcripts exhibiting two- to three-fold change. A full data set appears in 1. Superscript numerals represent the number of probe sets concordant for changed expression for a given gene. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type. | ||||||
Eng et al. Neural Development 2007 2:3 doi:10.1186/1749-8104-2-3 |
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