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Transcripts decreased in the DRG of Brn3a null mice |
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| Transcript |
Symbol |
Class |
WT |
HT |
KO |
WT/KO |
|
|
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| Limb expression 1 |
Lix1 |
Unk |
984 |
923 |
46 |
21.4 |
| Vascular endothelial growth factor C |
Vegfc |
Dev |
55 |
54 |
3 |
16.1 |
| Neural cell adhesion molecule 2 |
Ncam22 |
AX |
280 |
212 |
22 |
12.9 |
| Runt related 3 |
Runx3 |
TX |
251 |
421 |
22 |
11.3 |
| Brn3b |
Pou4f2 |
TX |
613 |
772 |
61 |
10.0 |
| Brn3a |
Pou4f12 |
TX |
1,107 |
1,119 |
115 |
9.6 |
| Phospholipase A2, group VII |
Pla2g7 |
ST |
618 |
438 |
77 |
8.1 |
| K+ channel, shaker-related, member 1 |
Kcna13 |
NT |
438 |
523 |
59 |
7.4 |
| Advillin |
Avil |
AX |
2,494 |
1,735 |
364 |
6.9 |
| Galanin |
Gal |
NT |
5,388 |
4,414 |
824 |
6.5 |
| Basonuclin 1 |
Bnc1 |
TX |
875 |
740 |
165 |
5.3 |
| Insulin-like growth factor 1 |
Igf13 |
Dev |
820 |
609 |
160 |
5.1 |
| G protein-coupled receptor 64 |
Gpr642 |
NT |
371 |
298 |
72 |
5.1 |
| Adenylate cyclase activating polypeptide 1, PACAP |
Adcyap1 |
NT |
283 |
198 |
57 |
5.0 |
| Regulator of G-protein signaling 10 |
Rgs10 |
NT |
1,793 |
1,596 |
362 |
5.0 |
| Parvalbumin |
Pvalb |
ST |
403 |
223 |
95 |
4.3 |
| K+ channel, shaker-related, beta member 2 |
Kcnab2 |
NT |
952 |
684 |
238 |
4.0 |
| Diacylglycerol kinase, eta |
Dgkh2 |
ST |
1,348 |
1,230 |
353 |
3.8 |
| G protein-coupled receptor 73 |
Gpr73 |
NT |
336 |
157 |
90 |
3.7 |
| Serine proteinase inhibitor, clade A, member 3G; Spi2A |
Serpina3g |
Other |
426 |
346 |
116 |
3.7 |
| Copine IV |
Cpne4 |
Unk |
767 |
636 |
216 |
3.6 |
| PQ loop repeat containing 1 |
Pqlc1 |
Unk |
911 |
596 |
259 |
3.5 |
| Reticulon 4 receptor-like 2; nogo receptor-like 3 |
Rtn4rl2 |
AX |
789 |
694 |
226 |
3.5 |
| Spermatogenesis associated glutamate-rich protein 1 |
Speer1-ps1 |
Unk |
349 |
307 |
106 |
3.3 |
| Pappalysin 2 |
Pappa2 |
Other |
694 |
794 |
225 |
3.1 |
| Brn3c |
Pou4f3 |
TX |
394 |
361 |
130 |
3.0 |
| Protein tyrosine phosphatase, receptor type, J |
Ptprj |
ST |
853 |
918 |
284 |
3.0 |
| Docking protein 4 |
Dok4 |
ST |
2,014 |
1655 |
679 |
3.0 |
| Selected |
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| Eph receptor A7 |
Epha7 |
AX |
206 |
202 |
77 |
2.7 |
| Latexin |
Lxn |
NT? |
2,948 |
2,564 |
1,105 |
2.7 |
| DRG11 |
Prrxl1 |
TX |
1,514 |
1,339 |
569 |
2.7 |
| Protein tyrosine phosphatase, non-receptor type 3 |
Ptpn3 |
ST |
1,638 |
1,881 |
623 |
2.6 |
| GABA-A receptor, subunit alpha 2 |
Gabra2 |
NT |
62 |
90 |
24 |
2.6 |
| Na+ channel, type VII, alpha |
Scn7a |
NT |
1,199 |
1,386 |
506 |
2.4 |
| Protein tyrosine phosphatase, receptor type, R |
Ptprr |
ST |
3,376 |
3,207 |
1,467 |
2.3 |
| Rap1, GTPase-activating protein 1 |
Rap1ga1 |
ST |
1,721 |
1,686 |
749 |
2.3 |
| LIM domain binding 2 |
Ldb2 |
TX |
794 |
492 |
349 |
2.3 |
| Anthrax toxin receptor 2 |
Antxr2 |
Unk |
1,355 |
1,095 |
608 |
2.2 |
| Runt related txn factor 1 |
Runx1 |
TX |
360 |
343 |
162 |
2.2 |
| Homeobox D1 |
Hoxd1 |
TX |
852 |
751 |
404 |
2.1 |
| Inhibitor of DNA binding 1 |
Id1 |
TX |
1,248 |
1,051 |
624 |
2.0 |
|
All listed transcripts showed decreased expression (change p > 0.995) in two independent replicates. Complete data appear for all replicated changes above three-fold, and selected data appear for transcripts exhibiting change in the two- to three-fold range. A full data set appears in 2. Note that Brn3a transcripts are still detected in the Brn3a null genotype, consistent with the detection of the 3'-end of residual non-coding transcripts. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type. | ||||||
Eng et al. Neural Development 2007 2:3 doi:10.1186/1749-8104-2-3 |
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