Open Access Highly Accessed Research article

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors

Patrick Pla1,2,3*, Marie-Rose Hirsch1,2, Stéphane Le Crom4, Simone Reiprich1,2,5, Vincent R Harley6 and Christo Goridis1,2

1 Ecole normale supérieure, Département de Biologie, 75005 Paris, France

2 CNRS, UMR8542, 75005 Paris, France

3 UMR 146 Institut Curie-CNRS, Centre Universitaire, Bat. 110, 91405 Orsay cedex, France

4 IFR36, Plate-forme Transcriptome, Ecole normale supérieure, 75005 Paris, France

5 Institut für Biochemie, 91054 Erlangen, Germany

6 Human Molecular Genetics Laboratory, Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia

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Neural Development 2008, 3:14 doi:10.1186/1749-8104-3-14

Published: 19 June 2008

Additional files

Additional file 1:

Genes down-regulated in Phox2bLacZ/LacZ embryos. A list of the 51 genes that were found to be significantly down-regulated in the ventral r4 of Phox2bLacZ/LacZ embryos according to the criteria presented in Materials and methods (SAM score above 3.5). The expression of the genes written in red was tested by ISH in Phox2bLacZ/+ and Phox2bLacZ/LacZembryos.

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Additional file 2:

Genes up-regulated in Phox2bLacZ/LacZ embryos. A list of the 23 genes that were found to be significantly up-regulated in the ventral r4 of Phox2bLacZ/LacZ embryos according to the criteria presented in Materials and methods (SAM score below -3.5). The expression of the genes written in red was tested by ISH in Phox2bLacZ/+ and Phox2bLacZ/LacZembryos.

Format: DOC Size: 121KB Download file

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Open Data