Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development

Bruno C Bello , Natalya Izergina , Emmanuel Caussinus and Heinrich Reichert

Biozentrum, University of Basel, CH-4056 Basel, Switzerland

author email corresponding author email

Neural Development 2008, 3:5doi:10.1186/1749-8104-3-5


Published:	19 February 2008

Additional files

Additional file 1:

Time-lapse analysis of a proliferating dorsomedial NB clone. Cultured explant of larval brain. CD8::GFP and tau::GFP are used to mark cell membranes and mitotic spindles simultaneously. Each frame is a projection of a thick stack of confocal sections taken at 1 μm z-intervals. Frames were taken at 1-min intervals over an 810-min period. Two divisions of the large NB cell were observed during this period (red arrowheads) while many associated cells underwent mitosis giving rise to daughter cells of similar sizes (yellow arrowheads).

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