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Open Access Highly Accessed Research article

Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions

Gonzalo Alvarez-Bolado1*, Fabian A Paul23 and Sandra Blaess2*

Author Affiliations

1 Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany

2 Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany

3 Max-Delbrück-Centrum for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13092 Berlin, Germany

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Neural Development 2012, 7:4  doi:10.1186/1749-8104-7-4

Published: 20 January 2012

Additional files

Additional file 1:

Labeling Shh-expressing hypothalamic progenitor domains, TM7.5 to TM9.5. Series of transverse sections at low (left) and high (right) magnification through the E12.5 diencephalon showing the original lineage labeling at TM as indicated.

Format: PNG Size: 3.6MB Download file

Open Data

Additional file 2:

Labeling Shh-expressing hypothalamic progenitor domains, TM10.5 to TM12.5. Series of transverse sections at low (left) and high (right) magnification through the E12.5 diencephalon (E13.5 in the case of TM12.5) showing the original lineage labeling at TM as indicated.

Format: PNG Size: 3MB Download file

Open Data

Additional file 3:

Hypothalamic Shh-derived lineage in transverse sections. Two series of transverse sections through the mouse caudal hypothalamus at E18.5 labeled by the X-gal reaction after Shh-GIFM (TM as indicated). AHA, anterior hypothalamic region; ARH, arcuate nucleus; DMH, dorsomedial nucleus; fr,

    retroflex fascicle
; LH, lateral hypothalamus; MBO, mammillary body; ME, median eminence; mth, mammillothalamic tract; PH, posterior hypothalamus; RCh, retrochiasmatic nucleus; SUM, supramammillary nucleus; VMH, ventromedial nucleus.

Format: PNG Size: 5.5MB Download file

Open Data