Genetic deletion of NeuroD2 leads to cell-type-specific effects on classic spine density. (A) Representative CA3 tertiary dendritic segments showing classical spines at P14 and P21. (B) Quantification of mean classical spine density on CA3 tertiary segments (n ≥ 9 per condition). (C) Quantification of mean CA3 classical spine head width (n ≥ 9 per condition). (D) Quantification of DG spine density (WT, n = 7; knockout (KO), n = 8). (E) Quantification of CA1 spine density (WT, n = 13; KO, n = 7). *P < 0.05, ***P < 0.001, t-test. Scale bar: 5 μm. Error bars represent ± standard error of the mean.
Wilke et al. Neural Development 2012 7:9 doi:10.1186/1749-8104-7-9