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Neurogenesis in zebrafish – from embryo to adult

Rebecca Schmidt, Uwe Strähle and Steffen Scholpp*

Author Affiliations

Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics (ITG), 76021, Karlsruhe, Germany

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Neural Development 2013, 8:3  doi:10.1186/1749-8104-8-3

Published: 21 February 2013

Abstract

Neurogenesis in the developing central nervous system consists of the induction and proliferation of neural progenitor cells and their subsequent differentiation into mature neurons. External as well as internal cues orchestrate neurogenesis in a precise temporal and spatial way. In the last 20 years, the zebrafish has proven to be an excellent model organism to study neurogenesis in the embryo. Recently, this vertebrate has also become a model for the investigation of adult neurogenesis and neural regeneration. Here, we summarize the contributions of zebrafish in neural development and adult neurogenesis.